calyr.aí · 2026
Surrogate.
Oracle.
A surrogate makes expensive physics fast.
An oracle chooses what must be tested next.
01
Evidence
measurements · simulations · constraints
→
02
Surrogate
expensive physics becomes fast prediction
→
03
Oracle
prediction + uncertainty → next experiment
→
04
Experiment
test the most consequential uncertainty
Active projects · Surrogate → Oracle
01
p-tec
Therapeutic design
Surrogate → Oracle · Nanoparticle & AAV design
Sequence model · cVAE · Bayesian optimization · Retrograde transport
Executive summary →
02
a-tex
Vascular research
Surrogate → Oracle · Vascular targeting & intervention
SAXS · SPR · 6-task oracle · CaCl₂-AAA model · Dual-screen evidence
Executive summary →
03
bp-tec
Biophysics
Surrogate → Oracle · Biophysical signal inference
SPR · SAXS · Cryo-EM · Multi-scale surrogate · Hidden state oracle
Executive summary →